The popular weight loss medications produced different results in patients who participated in a trial, and here’s what researchers found.

A larger waist circumference is associated with a higher risk of all-cause mortality and decreased life expectancy. Meanwhile, the group taking Zepbound (sold as Mounjaro for weight loss in some markets) also saw greater improvements in blood pressure, blood glucose, and cholesterol levels.

A new study shows that people Zepbound lost about 50% more weight than those using Wegovy. It was the first head-to-head trial of the blockbuster weight-loss medications.