Christina Applegate and Jamie-Lynn Sigler discuss differences in how they live with multiple sclerosis in an emotional ...

The Sopranos' actress says her own experience coping with MS has helped with her 11-year-old son's remarkable recovery from a rare autoimmune condition Jamie-Lynn Sigler's 11-year-old son Beau was ...

Jamie-Lynn Sigler’s 10-Year-Old Son Beau Leaves Hospital 33 Days After ‘Nightmare’ Diagnosis Jamie-Lynn Sigler Reveals Son Beau Has Been Diagnosed with Autoimmune Disorder After Catching a ...

“I just didn’t know what that would mean for me to say it out loud and have everybody know,” Jamie-Lynn Sigler says in PEOPLE’s exclusive clip of her and Christina Applegate’s new ...

Christina Applegate got emotional opening up about her struggle with multiple sclerosis, nearly four years after she was ...

Jamie-Lynn Sigler is going up against her Sopranos brother, Robert Iler, on The $100,000 Pyramid! In PEOPLE's exclusive look at the March 23 episode of the game show, the two former costars ...

Applegate revealed in an episode of the podcast "MeSsy," which she co-hosts with fellow actress Jamie-Lynn Sigler, that she's been in and out of urgent care constantly since being diagnosed with ...

The "Dead to Me" star shared the toll that multiple sclerosis has taken on her body and digestive system since she was diagnosed in 2021.

Christina Applegate is letting fans in on some of the details of her struggle against MS over the past three years.