BACKGROUND Mucins play an important protective role in the colonic mucosa. Luminal factors modulating colonic mucus release have been not fully identified. AIM To determine the effect of some dietary ...

Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for ...

Background The National Health Service Bowel Cancer Screening Programme (BCSP) in England uses a guaiac-based faecal occult blood test (gFOBt). A quantitative faecal immunochemical test (FIT) for ...

Methods Fecal samples were collected from CRC patients and healthy controls, and virus-like particles (VLPs) were isolated. PacBio sequencing platforms were used to sequence VLP DNA with a minimum ...

Introduction Gastroenterology specialist registrars in the northeast of England will rotate through a tertiary liver transplant centre. This role requires specialist knowledge of liver transplant and ...

Objective Colorectal cancer (CRC) is the third most common cancer worldwide. The geographical and temporal burden of this cancer provides insights into risk factor prevalence and progress in cancer ...

Pancreatic cancer remains one of the most aggressive tumours with a 5-year survival rate of less than 5%. The dismal prognosis of this tumour entity that is associated with a high degree of drug ...

Aims and background Psychological stress accompanies chronic inflammatory diseases such as IBD, and stress hormones can exacerbate pain signalling. In contrast, the endogenous opioid system has an ...

Professor Okuda sets out the aim of this book which is to describe advances in various imaging modalities to facilitate the use of different techniques and contribute to the understanding of ...

Objective Alcohol use in metabolic dysfunction-associated steatohepatitis (MASH) is associated with an increased risk of fibrosis and liver-related death. Here, we aimed to identify a mechanism ...

The intestinal microbiota, a conglomerate of microorganisms comprising bacteria, viruses, archaea and fungi, has been recognised as an important component of host physiology through, for example, its ...

Results GPR171 was markedly increased in inflamed mucosa and CD4 + T cells of patients with IBD compared with controls. BigLEN-triggered GPR171 activation inhibited Th17 cell differentiation in vitro.